This is Pilot Mountain, NC, also known to viewers of The Andy Griffith Show and Mayberry, RFD as Mt. Pilot. It lies south of Mount Airy, NC (Mayberry), on Route 52.
Here is a slightly closer view. I took these pics while I was on my way to Charleston, WV last August. I have probably seen this view at least 125 times in the last 38 years. It was relatively clear that day, but sometimes it is shrouded in mist, low clouds or fog.
The last one was taken a week later, when I was headed back south. I took this one through the windshield while cruising around 70 mph. Read about the mountain here.